SR9009: A New Hope for Night-Shift Workers and People with Insomnia

Prof. Stacks · Jan 18, 2024

Have you ever struggled to stay awake during your night shift or tossed and turned all night unable to sleep? Imagine a medicine that could help with these problems. That's where SR9009 comes in, and it's pretty exciting!

First, let's talk about something called circadian clock proteins. These are like tiny clocks inside our bodies that help control when we grow, how our body uses energy, and even how we stay healthy. SR9009 is a special kind of medicine that works on these clocks.

Now, the main focus of SR9009 has been on a type of lung cancer called SCLC (small cell lung cancer). Researchers found that SR9009 can be really effective against this cancer. It even helps when other cancer treatments don't work well. This is because SR9009 targets specific parts of our body's clocks called REV-ERBs. It's like hitting a bullseye in treating this kind of cancer!

In our study, we discovered that cells from this lung cancer have a lot of a certain REV-ERB (called REV-ERBα), but not much of another (REV-ERBβ). This was important because it showed us that REV-ERBα is the main target of SR9009 in fighting this cancer.

We also learned that SR9009 affects a process in our cells called autophagy. This process is like a recycling system in our cells. It helps get rid of things the cell doesn't need anymore. But in cancer cells, this system sometimes helps them survive. SR9009 works by messing with a key part of this system, a protein called Atg5, making it hard for cancer cells to survive.

In simple terms, SR9009 stops the cancer cells from recycling things they need to stay alive. This is great news for treating this type of lung cancer.

But what does this have to do with night-shift workers and people with insomnia? Well, because SR9009 works on our body's clocks, it could help reset our sleep patterns. This means it might help people who have trouble sleeping or who need to stay awake at odd hours, like during a night shift. It's like giving your body's clock a gentle nudge to help it run more smoothly.

In conclusion, SR9009 is showing a lot of promise, not just for treating a tough kind of lung cancer but also for helping people with sleep problems. It's a great example of how understanding our body's inner workings can lead to exciting new treatments. Who knows? In the future, SR9009 could become a go-to solution for those sleepless nights or tough night shifts!

Source: Shen, W., Zhang, W., Ye, W., Wang, H., Zhang, Q., Shen, J., Hong, Q., Li, X., Wen, G., Wei, T., & Zhang, J. (2020). SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy. Theranostics, 10(10), 4466–4480. https://doi.org/10.7150/thno.42478

SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy

Rationale: The circadian clock coordinates cell proliferation and metabolism and impacts the progression of some diseases, particularly cancer. Pharmacological modulation of the circadian machinery may be an effective therapeutic approach for treating ...

www.ncbi.nlm.nih.gov

SR9009: A New Hope for Night-Shift Workers and People with Insomnia

Prof. Stacks

Administrator

Have you ever struggled to stay awake during your night shift or tossed and turned all night unable to sleep? Imagine a medicine that could help with these problems. That's where SR9009 comes in, and it's pretty exciting!​

First, let's talk about something called circadian clock proteins. These are like tiny clocks inside our bodies that help control when we grow, how our body uses energy, and even how we stay healthy. SR9009 is a special kind of medicine that works on these clocks.​

In our study, we discovered that cells from this lung cancer have a lot of a certain REV-ERB (called REV-ERBα), but not much of another (REV-ERBβ). This was important because it showed us that REV-ERBα is the main target of SR9009 in fighting this cancer.​

In simple terms, SR9009 stops the cancer cells from recycling things they need to stay alive. This is great news for treating this type of lung cancer.​

​

SR9009 induces a REV-ERB dependent anti-small-cell lung cancer effect through inhibition of autophagy

Have you ever struggled to stay awake during your night shift or tossed and turned all night unable to sleep? Imagine a medicine that could help with these problems. That's where SR9009 comes in, and it's pretty exciting!

First, let's talk about something called circadian clock proteins. These are like tiny clocks inside our bodies that help control when we grow, how our body uses energy, and even how we stay healthy. SR9009 is a special kind of medicine that works on these clocks.

In our study, we discovered that cells from this lung cancer have a lot of a certain REV-ERB (called REV-ERBα), but not much of another (REV-ERBβ). This was important because it showed us that REV-ERBα is the main target of SR9009 in fighting this cancer.

In simple terms, SR9009 stops the cancer cells from recycling things they need to stay alive. This is great news for treating this type of lung cancer.